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Endocrine Abstracts

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ea0029p1213 | Obesity | ICEECE2012

SUR2a gene is upregulated in skeletal muscle insulin resistance of obese rats: correlation with GLUT4 gene

Felipe dos Santos Ferreira Marques M. , Cristina Tieko Mori R. , Mitiko Okamoto M. , Fabres Machado U.

Objective: The aim of this study was to investigate whether SUR2A (sulfonylurea receptor type 2A, ABCC9) MEF2a (myocyte enhancer factor-2a) and HIF1a (Hypoxia-inducible factor-1) can influence glucose uptake in oxidative muscle soleus by regulating GLUT4 expression.Methods: Insulin resistance was induced in male Wistar rats by inducing obesity with monosodium glutamate (MSG). At the age 3 months, half control and MSG-treated animals started receiving 0.1...
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ea0026p338 | Obesity | ECE2011

Glimepiride improves insulin sensitivity in oxidative skeletal muscle of obese rats: possible association between GLUT4 and SUR2A expressions

Felipe dos Santos Ferreira Marques M F S F M , Cristina Tieko Mori R C T M , Mitiko Okamoto M M O , Fabres Machado U F M

Studies have demonstrated that ATP-sensitive potassium channel (KATP) subunits SUR2A (sulfonylurea receptor) and KIR6.2 are involved in glucose uptake into skeletal muscle. It is known that the glucose transporter 4 (GLUT4) expression is highest in oxidative type I fibers, pointing out the important role of oxidative muscles as glucose uptakes. Considering these aspects the aim of this study was to investigate whether KATP channel can influence glucose uptake in oxidative musc...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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